- Sacred
- SaGa Series
- Saiyuki - Journey West
- Sakura Wars - So Long, My Love
- Samurai Legend Musashi
- Sea Dogs
- Seiken Densetsu Series
- Septerra Core
- ShadowFlare
- Shadowgate Series
- Shadow Hearts Series
- Shadow Madness
- Shady O' Grady's Rising Star
- Shattered Light
- Shining Force Series
- Shin Megami Tensei - Devil Summoner Series
- Siege of Avalon
- Silver
- Silverfall
- Skies of Arcadia Series
- Soulbringer
- Soul Blazer Series
- Soul Nomad & the World Eaters
- Space Hack
- Space Siege
- Spectral Force 3
- Spectrobes
- Star Ocean Series
- Stella Deus - The Gate of Eternity
- Stormbringer
- Sudeki
- Suikoden Series
- Summoner Series
- Summoning, The
- Summon Night Series
- Super Columbine Massacre RPG
- Swords of Glass
Also see:
- ..Saga of Heroes(5)
- ..Savage Eden - The Battle for Laghaim(1)
- ..Serpent Isle(2)
- ..Shadowbane(4)
- ..Shadows of Angmar(39)
- ..Shaiya(2)
- ..Silkroad Online(2)
- ..Silver Star Story(1)
- ..Sith Lords, The(1)
- ..Stargate Worlds(1)
- ..Star Trek Online(37)
- ..Star Wars - Knights of the Old Republic Series(39)
- ..Star Wars - The Old Republic(36)
- ..Star Wars Galaxies(22)
- ..Stormreach(9)
- ..Stygian Abyss, The(1)
- ..Subspace(3)
- ..Super Mario RPG Series(2)
- ..The Saga of Ryzom(4)